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Why CBD

Benefit from CBD Products

Cannabidiol, or CBD as it is commonly known, is one of more than 100 cannabinoids that is naturally produced in cannabis plants.  Other cannabinoids include tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), and cannabichromene (CBC). CBD does not have any of the psychoactive effects (i.e. “the high”) that is associated with the use of THC. Our products contain less than 0.3% THC. Learn more about CBD below.

NOTE:
Before reading more about CBD, make sure you consult your physician or other medical professional prior to taking CBD. The scientific studies listed below do not represent you or your specific conditions. Many of the studies below are preclinical and have not been re-studied in humans.

DISCLAIMERS:
The statements on our website have not been evaluated by the Food and Drug Administrations. P•H•A•R•M CBD products are not intended to diagnose, treat, cure, or prevent any disease. The studies that are described on this page were not conducted by P•H•A•R•M CBD, LLC. They are provided for informational purposes only. We encourage all people interested in CBD to do their own research on the risks and benefits of CBD prior to taking it. P•H•A•R•M CBD, LLC is not liable for damages arising from the use of this information.

Scientific Studies

Preclinical and clinical investigations have studied a wide variety of health benefits of CBD, including:

CBD has been shown to have anti-inflammatory effects in vitro, in vivo, and ex vivo  [1, 2].  Inflammation has been linked to a host of diseases and health-related issues including many types of pain [3], neurological damage [4], diabetes [5], and arthritis [6].

Alzheimer’s, dementia, Parkinson’s, multiple sclerosis, epilepsy, Huntington’s chorea, stroke, traumatic brain injury

Some studies have indicated that CBD may reduce epileptic seizures [8] and provide neuroprotective effects to potentially reduce the risk for Alzheimer’s [9].

People who suffer from anxiety [9]  and depression [10] may also benefit from the effects of CBD.

According to the National Institute of Health, manipulating the endocannabinoid system by introducing external cannabinoids like CBD could be useful in regulating a variety of other medical ailments, including:

Endocannabinoid System: The endocannabinoid system (ECS) is a complex cell-signaling system identified in the early 1990s by researchers exploring THC. The ECS is functioning in your body, even if you don’t use cannabis. Our bodies naturally produce endocannabinoids and these receptors have shown to function more efficiently when phytocannabinoids are introduced, i.e. CBD oil

Two main endocannabinoid receptors:

  • CB1 receptors, which are mostly found in the central nervous system
  • CB2 receptors, which are mostly found in your peripheral nervous system, especially immune cells.

CBD works with our bodies endocannabinoid system (ECS) to regulate a broad range of physiological processes that affect our everyday experience – our mood, our energy level, our intestinal fortitude, immune activity, blood pressure, bone density, glucose metabolism, how we experience pain, stress, hunger, and more.

If you imagine the body like a machine, each system works together to keep the machine moving. The immune system is like a filtration system, the brain is like the motherboard, and endocannabinoids help to maintain these systems.

  • THC is a partial agonist and binds to CB1 receptors.
    • Similar to endogenous (endocannabinoid) anandamide
  • CBD is a endocannabinoid modulator
    • No direct affinity for CB1 and CB2 receptors
    • Decreases psychotropic activity of THC
      • Inhibits hepatic metabolism of THC to more psychoactive metabolite
    • Enhances activity of endogenous cannabinoid anandamide
      • Prevents enzymatic degradation

Below is a list of additional studies that investigate the potential benefits of CBD:

Esposito, Giuseppe, et al. PloS one 6.12 (2011): e28668

O’Connell, Brooke K., David Gloss, and Orrin Devinsky.  Ep. & Behavior 70 (2017): 341-348.

Leweke, F. M., et al.  Translational psychiatry 2.3 (2012): e94.

Shrivastava, Ashutosh, et al. Molecular Can. therapeutics (2011): molcanther-1100.

McAllister, Sean D., et al.  Breast Can. research and treatment 129.1 (2011): 37-47.

Ramer, Robert, et al.  Biochemical pharmacology 79.7 (2010): 955-966.

NOTE:
Before reading more about CBD, make sure you consult your physician or other medical professional prior to taking CBD. The scientific studies listed below do not represent you or your specific conditions. Many of the studies below are preclinical and have not been re-studied in humans.

DISCLAIMERS:
The statements on our website have not been evaluated by the Food and Drug Administrations. P•H•A•R•M CBD products are not intended to diagnose, treat, cure, or prevent any disease. The studies that are described on this page were not conducted by P•H•A•R•M CBD, LLC. They are provided for informational purposes only. We encourage all people interested in CBD to do their own research on the risks and benefits of CBD prior to taking it. P•H•A•R•M CBD, LLC is not liable for damages arising from the use of this information.